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1

A Jerusalem chant for the Holy Cross in the Byzantine, Latin and Eastern Rites

Dubowchik, Rosemary Thoonen

Journal:

Plainsong and Medieval Music

Year:

1996

Language:

english

File:

PDF, 1.07 MB

english, 1996

2

Cathepsin B-Labile Dipeptide Linkers for Lysosomal Release of Doxorubicin from Internalizing Immunoconjugates: Model Studies of Enzymatic Drug Release and Antigen-Specific In Vitro Anticancer Activity

Dubowchik, Gene M., Firestone, Raymond A., Padilla, Linda, Willner, David, Hofstead, Sandra J., Mosure, Kathleen, Knipe, Jay O., Lasch, Shirley J., Trail, Pamela A.

Journal:

Bioconjugate Chemistry

Year:

2002

Language:

english

File:

PDF, 190 KB

english, 2002

3

Singing with the Angels: Foundation Documents as Evidence for Musical Life in Monasteries of the Byzantine Empire

Rosemary Dubowchik

Journal:

Dumbarton Oaks Papers

Year:

2002

Language:

english

File:

PDF, 2.98 MB

english, 2002

4

Cathepsin B-sensitive dipeptide prodrugs. 1. A model study of structural requirements for efficient release of doxorubicin

Gene M. Dubowchik, Raymond A. Firestone

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 367 KB

english, 1998

5

The Exultet in Southern Italyby Thomas Forrest Kelly

Review by: Rosemary Thoonen Dubowchik

Journal:

Year:

1997

Language:

english

File:

PDF, 109 KB

english, 1997

6

Stereoselective Synthesis of New Conformationally Restricted Analogues of a Potent CGRP Receptor Antagonist

Zuev, Dmitry, Michne, Jodi A., Huang, Hong, Beno, Brett R., Wu, Dedong, Gao, Qi, Torrente, John R., Xu, Cen, Conway, Charles M., Macor, John E., Dubowchik, Gene M.

Journal:

Organic Letters

Year:

2005

Language:

english

File:

PDF, 132 KB

english, 2005

7

Rimegepant, an Oral Calcitonin Gene–Related Peptide Receptor Antagonist, for Migraine

Lipton, Richard B., Croop, Robert, Stock, Elyse G., Stock, David A., Morris, Beth A., Frost, Marianne, Dubowchik, Gene M., Conway, Charles M., Coric, Vladimir, Goadsby, Peter J.

Journal:

New England Journal of Medicine

Year:

2019

File:

PDF, 263 KB

2019

8

ChemInform Abstract: Monomethoxytrityl (MMT) as a Versatile Amino Protecting Group for Complex Prodrugs of Anticancer Compounds Sensitive to Strong Acids, Bases and Nucleophiles.

G. M. DUBOWCHIK, S. RADIA

Journal:

Year:

1997

File:

PDF, 27 KB

1997

9

ChemInform Abstract: Efficient Mitomycin C Coupling with Stable p-Nitrophenyl Benzyl Carbonates Using N-Hydroxybenzotriazole as a Catalytic Additive.

G. M. DUBOWCHIK, H. D. KING, K. PHAM-KAPLITA

Journal:

Year:

1997

File:

PDF, 27 KB

1997

10

ChemInform Abstract: Facile Synthesis of Maleimide Bifunctional Linkers.

H. Dalton King, Gene M. Dubowchik, Michael A. Walker

Journal:

Year:

2002

File:

PDF, 28 KB

2002

11

2-Arylaminothiazoles as High-Affinity Corticotropin-Releasing Factor 1 Receptor (CRF1R) Antagonists: Synthesis, Binding Studies and Behavioral Efficacy.

Gene M. Dubowchik, et al. et al.

Journal:

Year:

2004

File:

PDF, 104 KB

2004

12

An Efficient Sequence for the Preparation of Small Secondary Amine Hydrochloride Salts for Focused Library Generation Without Need for Distillation or Chromatographic Purification.

Gene M. Dubowchik, Jodi A. Michne, Dmitry Zuev

Journal:

Year:

2004

File:

PDF, 26 KB

2004

13

Synthesis, Structure—Activity Relationships, and Anxiolytic Activity of 7-Aryl-6,7-dihydroimidazoimidazole Corticotropin-Releasing Factor 1 Receptor Antagonists.

Xiaojun Han, Gene M. Dubowchik, et al. et al.

Journal:

Year:

2005

File:

PDF, 18 KB

2005

14

Synthesis and Structure—Activity Relationship of Imidazo[1,2-a]benzimidazoles (XII) as Corticotropin-Releasing Factor 1 Receptor Antagonists.

Xiaojun Han, Sokhom S. Pin, Kevin Burris, Lawrence K. Fung, Stella Huang, Matthew T. Taber, Jie Zhang, Gene M. Dubowchik

Journal:

Year:

2005

File:

PDF, 39 KB

2005

15

A lipophilic polyamino-bolaamphiphile designed to dissipate pH gradients across a bilayer membrane: Synthesis and proton transport

Gene M. Dubowchik, Raymond A. Firestone

Journal:

Tetrahedron Letters

Year:

1996

Language:

english

File:

PDF, 250 KB

english, 1996

16

Monoclonal antibody mediated intracellular targeting of tallysomycin S10b

Michael A Walker, H.Dalton King, Richard A Dalterio, Pamela Trail, Raymond Firestone, Gene M Dubowchik

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 277 KB

english, 2004

17

Tetrahydroisoquinoline derivatives as melatonin MT2 receptor antagonists

George N. Karageorge, Stephen Bertenshaw, Lawrence Iben, Cen Xu, Nathan Sarbin, Anthony Gentile, Gene M. Dubowchik

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 255 KB

english, 2004

18

Synthesis, structure–activity relationships, and anxiolytic activity of 7-aryl-6,7-dihydroimidazoimidazole corticotropin-releasing factor 1 receptor antagonists

Xiaojun Han, Jodi A. Michne, Sokhom S. Pin, Kevin D. Burris, Lynn A. Balanda, Lawrence K. Fung, Tracey Fiedler, Kaitlin E. Browman, Matthew T. Taber, Jie Zhang, Gene M. Dubowchik

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 230 KB

english, 2005

19

An orally active corticotropin releasing factor 1 receptor antagonist from 8-aryl-1,3a,7,8-tetraaza-cyclopenta[a]indenes

Xiaojun Han, Rita Civiello, Sokhom S. Pin, Kevin Burris, Lynn A. Balanda, Jay Knipe, Shelly Ren, Tracey Fiedler, Kaitlin E. Browman, Robert Macci, Matthew T. Taber, Jie Zhang, Gene M. Dubowchik

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 152 KB

english, 2007

20

Carbamates as potent calcitonin gene-related peptide antagonists with improved solution stability

Andrew P. Degnan, Charles M. Conway, Richard A. Dalterio, Robert Macci, Stephen E. Mercer, Richard Schartman, Cen Xu, Gene M. Dubowchik, John E. Macor

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 1.09 MB

english, 2009

21

Discovery of 6-chloro-2-trifluoromethyl-7-aryl-7H-imidazo[1,2-a]imidazol-3-ylmethylamines, a novel class of corticotropin-releasing factor receptor type 1 (CRF1R) antagonists

Dmitry Zuev, Vivekananda M. Vrudhula, Jodi A. Michne, Bireshwar Dasgupta, Sokhom S. Pin, Xiaohua Stella Huang, Dedong Wu, Qi Gao, Jie Zhang, Matthew T. Taber, John E. Macor, Gene M. Dubowchik

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 702 KB

english, 2010

22

Enantioselective synthesis of aminobenzazepinones

C.V.C. Prasad, Stephen E. Mercer, Gene M. Dubowchik, John E. Macor

Journal:

Tetrahedron Letters

Year:

2007

Language:

english

File:

PDF, 159 KB

english, 2007

23

An efficient synthesis of N-arylated, orthogonally protected racemic aspartates

Guanglin Luo, Ling Chen, Rita Civiello, Gene M. Dubowchik

Journal:

Tetrahedron Letters

Year:

2008

Language:

english

File:

PDF, 125 KB

english, 2008

24

Syntheses of aza and fluorine-substituted 3-(piperidin-4-yl)-4,5-dihydro-1H-benzo[d][1,3]diazepin-2(3H)-ones

Xiaojun Han, Rita L. Civiello, Stephen E. Mercer, John E. Macor, Gene M. Dubowchik

Journal:

Tetrahedron Letters

Year:

2009

Language:

english

File:

PDF, 178 KB

english, 2009

25

Enantioselective synthesis of constrained phenylalanine analogues

Prasad V. Chaturvedula, Stephen E. Mercer, Leatte Guernon, John E. Macor, Gene M. Dubowchik

Journal:

Tetrahedron Letters

Year:

2010

Language:

english

File:

PDF, 1.58 MB

english, 2010

26

The synthesis of branched steroidal prodrugs of nitrogen mustard for antitumor targeting via reconstituted LDL

Gene M. Dubowchik, Raymond A. Firestone

Journal:

Tetrahedron Letters

Year:

1994

Language:

english

File:

PDF, 281 KB

english, 1994

27

Facile synthesis of maleimide bifunctional linkers

H.Dalton King, Gene M Dubowchik, Michael A Walker

Journal:

Tetrahedron Letters

Year:

2002

Language:

english

File:

PDF, 104 KB

english, 2002

28

Monomethoxytrityl (MMT) as a versatile amino protecting group for complex prodrugs of anticancer compounds sensitive to strong acids, bases and nucleophiles

Gene M. Dubowchik, Shilpa Radia

Journal:

Tetrahedron Letters

Year:

1997

Language:

english

File:

PDF, 244 KB

english, 1997

29

Efficient mitomycin C coupling with stable p-nitrophenyl-benzyl carbonates using n-hydroxybenzotriazole as a catalytic additive

Gene M. Dubowchik, H. Dalton King, Kahnie Pham-Kaplita

Journal:

Tetrahedron Letters

Year:

1997

Language:

english

File:

PDF, 211 KB

english, 1997

30

Fluoresceinated FKBP12 ligands for a high-throughput fluorescence polarization assay

Gene M Dubowchik, Jonathan L Ditta, John J Herbst, Sagarika Bollini, Alexander Vinitsky

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 173 KB

english, 2000

31

Synthesis of an immunoconjugate of camptothecin

Michael A Walker, Gene M Dubowchik, Sandra J Hofstead, Pamela A Trail, Raymond A Firestone

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 112 KB

english, 2002

32

An acid-cleavable linker stable at neutral pH that releases doxorubicin at lysosomal pH

Gene M. Dubowchik, Linda M. Padilla, Raymond A. Firestone

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 272 KB

english, 1993

33

Cephalosporin prodrugs of paclitaxel for immunologically specific activation by L-49-sFv-β-Lactamase fusion protein

Vivekananda M. Vrudhula, David E. Kerr, Nathan O. Siemers, Gene M. Dubowchik, Peter D. Senter

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 150 KB

english, 2003

34

Cathepsin B-sensitive dipeptide prodrugs. 2. Models of anticancer drugs paclitaxel (Taxol®), mitomycin C and doxorubicin

Gene M. Dubowchik, Kathleen Mosure, Jay O. Knipe, Raymond A. Firestone

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 367 KB

english, 1998

35

Monoclonal antibody drug immunoconjugates for targeted treatment of cancer

Pamela A. Trail, Dalton H. King, Gene M. Dubowchik

Journal:

Cancer Immunology, Immunotherapy

Year:

2003

Language:

english

File:

PDF, 238 KB

english, 2003

36

The in vitro effects of three lysosomotropic detergents against three human tumor cell lines

Gene M. Dubowchik, Susan L. Gawlak, Raymond A. Firestone

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 318 KB

english, 1995

37

2-Arylaminothiazoles as high-affinity corticotropin-Releasing factor 1 receptor (CRF1R) antagonists: synthesis, binding studies and behavioral efficacy

Gene M. Dubowchik, Jodi A. Michne, Dmitry Zuev, Wendy Schwartz, Paul M. Scola, Clint A. James, Edward H. Ruediger, Sokhom S. Pin, Kevin D. Burris, Lynn A. Balanda, Qi Gao, Dedong Wu, Lawrence Fung, Tr

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 214 KB

english, 2003

38

An efficient sequence for the preparation of small secondary amine hydrochloride salts for focused library generation without need for distillation or chromatographic purification

Gene M. Dubowchik, Jodi A. Michne, Dmitry Zuev

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 242 KB

english, 2004

39

Optimization of CRF1R binding affinity of 2-(2,4,6-trichlorophenyl)-4-trifluoromethyl-5-aminomethylthiazoles through rapid and selective parallel synthesis

Dmitry Zuev, Jodi A. Michne, Sokhom S. Pin, Jie Zhang, Matthew T. Taber, Gene M. Dubowchik

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 258 KB

english, 2005

40

Synthesis and structure–activity relationship of imidazo[1,2-a]benzimidazoles as corticotropin-releasing factor 1 receptor antagonists

Xiaojun Han, Sokhom S. Pin, Kevin Burris, Lawrence K. Fung, Stella Huang, Matthew T. Taber, Jie Zhang, Gene M. Dubowchik

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 567 KB

english, 2005

41

Novel polyamide inducers of HL-60 cellular differentiation

Gene M. Dubowchik, Laurie A. Cornell, Alfred R. Crosswell, Raymond A. Firestone

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 394 KB

english, 1993

42

Doxorubicin immunoconjugates containing bivalent, lysosomally-Cleavable dipeptide linkages

Gene M Dubowchik, Shilpa Radia, Harold Mastalerz, Michael A Walker, Raymond A Firestone, H Dalton King, Sandra J Hofstead, David Willner, Shirley J Lasch, Pamela A Trail

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 133 KB

english, 2002

43

Amines That Transport Protons across Bilayer Membranes: Synthesis, Lysosomal Neutralization, and Two-Phase pKa Values by NMR

Dubowchik, Gene M., Padilla, Linda, Edinger, Kurt, Firestone, Raymond A.

Journal:

Journal of Organic Chemistry

Year:

1996

Language:

english

File:

PDF, 352 KB

english, 1996

44

Calcitonin gene-related peptide (CGRP) receptor antagonists: Pyridine as a replacement for a core amide group

Guanglin Luo, Ling Chen, Rita Civiello, Sokhom S. Pin, Cen Xu, Walter Kostich, Michelle Kelley, Charles M. Conway, John E. Macor, Gene M. Dubowchik

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 1.26 MB

english, 2012

45

Calcitonin gene-related peptide (CGRP) receptor antagonists: Novel aspartates and succinates

Guanglin Luo, Ling Chen, Sokhom S. Pin, Cen Xu, Charles M. Conway, John E. Macor, Gene M. Dubowchik

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 3.82 MB

english, 2012

46

Receptor-mediated and enzyme-dependent targeting of cytotoxic anticancer drugs

Gene M Dubowchik, Michael A Walker

Journal:

Pharmacology & Therapeutics

Year:

1999

Language:

english

File:

PDF, 657 KB

english, 1999

47

Catalytic Asymmetric Syntheses of Tyrosine Surrogates

Han, Xiaojun, Civiello, Rita L., Fang, Haiquang, Wu, Dedong, Gao, Qi, Chaturvedula, Prasad V., Macor, John E., Dubowchik, Gene M.

Journal:

Journal of Organic Chemistry

Year:

2008

Language:

english

File:

PDF, 514 KB

english, 2008

48

Reversal of doxorubicin resistance and catalytic neutralization of lysosomes by a lipophilic imidazole

Gene M. Dubowchik, Linda Padilla, Kurt Edinger, Raymond A. Firestone

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Year:

1994

Language:

english

File:

PDF, 566 KB

english, 1994

49

Design and synthesis of potent antagonists containing rigid spirocyclic privileged structures for the CGRP receptor

Prasad V. Chaturvedula, Sokhom Pin, George Tholady, Charlie M. Conway, John E. Macor, Gene M. Dubowchik

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 552 KB

english, 2012

50

Induction of cell death by the lysosomotropic detergent MSDH

Wei Li, XiMing Yuan, Gunnar Nordgren, Helge Dalen, Gene M. Dubowchik, Raymond A. Firestone, Ulf T. Brunk

Journal:

Year:

2000

Language:

english

File:

PDF, 675 KB

english, 2000

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